Adipose Tissue-Secreted Factors Alter Bladder Cancer Cell Migration.

ABSTRACT:

Background

Obesity is associated with an increased risk of bladder cancer recurrence. This study investigated the role of adipose tissue in bladder cancer progression.

Methods

Gene expression profiling was performed on adipose tissues collected from normal weight (n=5), overweight (n=11), and obese (n=10) patients with invasive bladder cancer, and adipose stromal cells (ASCs) were obtained from two normal weight, two overweight, and two obese patients. Conditioned media (CM) was characterized and evaluated for its effects on the proliferation, migration, and invasive potential of T24 bladder cancer cells.

Results

Expression profiling demonstrated depot-specific or body mass index-specific differences. Increased T24 cell migration was observed usin

SUBMITTER: Hariharan N 

PROVIDER: S-EPMC5985104 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature