MEGF10, a Glioma Survival-Associated Molecular Signature, Predicts IDH Mutation Status.

ABSTRACT: Glioma is the most common primary brain tumor with various genetic alterations; among which, IDH mutation is the most common mutation and plays an important role in glioma early development, especially in lower grade glioma (LGG, WHO II-III). Previous studies have found that IDH mutation is tightly associated with extensive methylation across whole genome in glioma. To further investigate the role of IDH, we obtained methylation data of 777 samples from CGGA (Chinese Glioma Genome Atlas) and TCGA (The Cancer Genome Atlas) with IDH mutation status available. A package compiled under R language called Tspair was used as the main analytic tool to find potential probes that were significantly affected by IDH mutation. As a result, we found one pair of probes, cg06940792 and cg

SUBMITTER: Li G 

PROVIDER: S-EPMC5985127 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature