Injectable, porous, biohybrid hydrogels incorporating decellularized tissue components for soft tissue applications.

ABSTRACT: Biodegradable injectable hydrogels have been extensively studied and evaluated in various medical applications such as for bulking agents, drug delivery reservoirs, temporary barriers, adhesives, and cell delivery matrices. Where injectable hydrogels are intended to facilitate a healing response, it may be desirable to encourage rapid cellular infiltration into the hydrogel volume from the tissue surrounding the injection site. In this study, we developed a platform technique to rapidly form pores in a thermally responsive injectable hydrogel, poly(NIPAAm-co-VP-co-MAPLA) by using mannitol particles as porogens. In a rat hindlimb muscle injection model, hydrogels incorporating porosity had significantly accelerated cellular infiltration. To influence the inflammatory response to the injecte

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC5985206 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature