Meloxicam increases epidermal growth factor receptor expression improving survival after hepatic resection in diet-induced obese mice.

ABSTRACT:

Background

Patients with fatty liver have delayed regenerative responses, increased hepatocellular injury, and increased risk for perioperative mortality. Currently, no clinical therapy exists to prevent liver failure or improve regeneration in patients with fatty liver. Previously we demonstrated that obese mice have markedly reduced levels of epidermal growth factor receptor in liver. We sought to identify pharmacologic agents to increase epidermal growth factor receptor expression to improve hepatic regeneration in the setting of fatty liver resection.

Methods

Lean (20% calories from fat) and diet-induced obese mice (60% calories from fat) were subjected to 70% or 80% hepatectomy.

Results

Using the BaseSpace Correlation Engine of deposited gene arrays we identified

SUBMITTER: Jin X 

PROVIDER: S-EPMC5985213 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature