Quantification of intramyocardial blood volume with ^99mTc-RBC SPECT-CT imaging: A preclinical study.

ABSTRACT:

Background

Currently, there is no established non-invasive imaging approach to directly evaluate myocardial microcirculatory function in order to diagnose microvascular disease independent of co-existing epicardial disease. In this work, we developed a methodological framework for quantification of intramyocardial blood volume (IMBV) as a novel index of microcirculatory function with SPECT/CT imaging of ^99mTc-labeled red blood cells (RBCs).

Methods

Dual-gated myocardial SPECT/CT equilibrium imaging of ^99mTc-RBCs was performed on twelve canines under resting conditions. Five correction schemes were studied: cardiac gating with no other corrections (CG), CG with attenuation correction (CG + AC), CG + AC with scatter correction (CG + AC + SC), dual cardior

SUBMITTER: Mohy-Ud-Din H 

PROVIDER: S-EPMC5985225 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature