Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons.

ABSTRACT:

Objective

Decreasing duodenal contraction is now considered as a major focus for the treatment of type 2 diabetes. Therefore, identifying bioactive molecules able to target the enteric nervous system, which controls the motility of intestinal smooth muscle cells, represents a new therapeutic avenue. For this reason, we chose to study the impact of oral galanin on this system in diabetic mice.

Methods

Enteric neurotransmission, duodenal contraction, glucose absorption, modification of gut-brain axis, and glucose metabolism (glucose tolerance, insulinemia, glucose entry in tissue, hepatic glucose metabolism) were assessed.

Results

We show that galanin, a neuropeptide expressed in the small intestine, decreases duodenal contraction by stimulating nitric oxide release fro

SUBMITTER: Abot A 

PROVIDER: S-EPMC5985240 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature