Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.

ABSTRACT: Fertilization is a fundamental process of development and is a prerequisite for successful human reproduction. In mice, although several receptor proteins have been shown to play important roles in the process of fertilization, only three genes have been shown to cause fertilization failure and infertility when deleted in vivo. In clinical practice, some infertility case subjects suffer from recurrent failure of in vitro fertilization and intracytoplasmic sperm injection attempts due to fertilization failure, but the genetic basis of fertilization failure in humans remains largely unknown. Wee2 is a key oocyte-specific kinase involved in the control of meiotic arrest in mice, but WEE2 has not been associated with any diseases in humans. In this study, we identified homozygous mutations in

SUBMITTER: Sang Q 

PROVIDER: S-EPMC5985286 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature