Computational Modeling of Hepatitis C Virus Envelope Glycoprotein Structure and Recognition.

ABSTRACT: Hepatitis C virus (HCV) is a major global health concern, and though therapeutic options have improved, no vaccine is available despite decades of research. As HCV can rapidly mutate to evade the immune response, an effective HCV vaccine must rely on identification and characterization of sites critical for broad immune protection and viral neutralization. This knowledge depends on structural and mechanistic insights of the E1 and E2 envelope glycoproteins, which assemble as a heterodimer on the surface of the virion, engage coreceptors during host cell entry, and are the primary targets of antibodies. Due to the challenges in determining experimental structures, structural information on E1 and E2 and their interaction is relatively limited, providing opportunities to model the structures

SUBMITTER: Guest JD 

PROVIDER: S-EPMC5985375 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature