Varying Immunizations With Plasmodium Radiation-Attenuated Sporozoites Alter Tissue-Specific CD8⁺ T Cell Dynamics.

ABSTRACT: Whole sporozoite vaccines represent one of the most promising strategies to induce protection against malaria. However, the development of efficient vaccination protocols still remains a major challenge. To understand how the generation of immunity is affected by variations in vaccination dosage and frequency, we systematically analyzed intrasplenic and intrahepatic CD8⁺ T cell responses following varied immunizations of mice with radiation-attenuated sporozoites. By combining experimental data and mathematical modeling, our analysis indicates a reversing role of spleen and liver in the generation of protective liver-resident CD8⁺ T cells during priming and booster injections: While the spleen acts as a critical source compartment during priming, the increase in vacci

SUBMITTER: Frank R 

PROVIDER: S-EPMC5985394 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature