Signaling events in pathogen-induced macrophage foam cell formation.

ABSTRACT: Macrophage foam cell formation is a key event in atherosclerosis. Several triggers induce low-density lipoprotein (LDL) uptake by macrophages to create foam cells, including infections with Porphyromonas gingivalis and Chlamydia pneumoniae, two pathogens that have been linked to atherosclerosis. While gene regulation during foam cell formation has been examined, comparative investigations to identify shared and specific pathogen-elicited molecular events relevant to foam cell formation are not well documented. We infected mouse bone marrow-derived macrophages with P. gingivalis or C. pneumoniae in the presence of LDL to induce foam cell formation, and examined gene expression using an atherosclerosis pathway targeted plate array. We found over 30 genes were significantly induced in respons

SUBMITTER: Shaik-Dasthagirisaheb YB 

PROVIDER: S-EPMC5985511 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature