Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans.

ABSTRACT: Ageing in man is associated with changes to the splicing factor pool. A proportion of splicing factors are regulated during ageing by mechanisms involving the Ataxia Telangiectasia Mutated (ATM) gene, but the factors that determine the remaining proportion have yet to be identified. DNA methylation is known to be an important regulatory mechanism of gene expression. We assessed age-associated methylation and expression levels for 27 splicing factor genes, in peripheral blood samples from the InCHIANTI study. Examination of splicing patterns at specific loci was examined in a second cohort, the Exeter 10000 study. 27/502 methylation probes in 17 different genes were associated with age. Most changes were not associated with transcript expression levels or splicing patterns, but hypomethylat

SUBMITTER: Holly AC 

PROVIDER: S-EPMC5985527 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature