A Brain-wide Circuit Model of Heat-Evoked Swimming Behavior in Larval Zebrafish.

ABSTRACT: Thermosensation provides crucial information, but how temperature representation is transformed from sensation to behavior is poorly understood. Here, we report a preparation that allows control of heat delivery to zebrafish larvae while monitoring motor output and imaging whole-brain calcium signals, thereby uncovering algorithmic and computational rules that couple dynamics of heat modulation, neural activity and swimming behavior. This approach identifies a critical step in the transformation of temperature representation between the sensory trigeminal ganglia and the hindbrain: A simple sustained trigeminal stimulus representation is transformed into a representation of absolute temperature as well as temperature changes in the hindbrain that explains the observed motor output. An acti

SUBMITTER: Haesemeyer M 

PROVIDER: S-EPMC5985529 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature