Evolutionary Rewiring of Human Regulatory Networks by Waves of Genome Expansion.

ABSTRACT: Genome expansion is believed to be an important driver of the evolution of gene regulation. To investigate the role of a newly arising sequence in rewiring regulatory networks, we estimated the age of each region of the human genome by applying maximum parsimony to genome-wide alignments with 100 vertebrates. We then studied the age distribution of several types of functional regions, with a focus on regulatory elements. The age distribution of regulatory elements reveals the extensive use of newly formed genomic sequence in the evolution of regulatory interactions. Many transcription factors have expanded their repertoire of targets through waves of genomic expansions that can be traced to specific evolutionary times. Repeated elements contributed a major part of such expansion: many clas

SUBMITTER: Marnetto D 

PROVIDER: S-EPMC5985534 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature