Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies.

ABSTRACT: Psychosocial adversity in childhood (e.g. abuse) and low socioeconomic position (SEP) can have significant lasting effects on social and health outcomes. DNA methylation-based biomarkers are highly correlated with chronological age; departures of methylation-predicted age from chronological age can be used to define a measure of age acceleration, which may represent a potential biological mechanism linking environmental exposures to later health outcomes. Using data from two cohorts of women Avon Longitudinal Study of Parents and Children, (ALSPAC), N = 989 and MRC National Survey of Health and Development, NSHD, N = 773), we assessed associations of SEP, psychosocial adversity in childhood (parental physical or mental illness or death, parental separation, parental absence, sub-optimal ma

SUBMITTER: Lawn RB 

PROVIDER: S-EPMC5985722 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature