Antiaging effects of a novel facial serum containing L-Ascorbic acid, proteoglycans, and proteoglycan-stimulating tripeptide: ex vivo skin explant studies and in vivo clinical studies in women.

ABSTRACT:

Background

With age, decreasing dermal levels of proteoglycans, collagen, and elastin lead to the appearance of aged skin. Oxidation, largely driven by environmental factors, plays a central role.

Aim

The aim of this study was to assess the antiaging efficacy of a topical serum containing L-Ascorbic acid, soluble proteoglycans, low molecular weight hyaluronic acid, and a tripeptide in ex vivo and in vivo clinical studies.

Methods

Photoaging and photo-oxidative damage were induced in human skin explants by artificial solar radiation. Markers of oxidative stress - reactive oxygen species (ROS), total glutathione (GSH), and cyclobutane pyrimidine dimers (CPDs) - were measured in serum-treated explants and untreated controls. Chronological aging was simulated using hydroc

SUBMITTER: Garre A 

PROVIDER: S-EPMC5985795 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature