Polymorphism in lncRNA AC008392.1 and its interaction with smoking on the risk of lung cancer in a Chinese population.

ABSTRACT:

Purpose

To evaluate the association between rs7248320 in lncRNA AC008392.1 and the risk of lung cancer, this case-control study was carried out in a Chinese population. This study also evaluated the gene-environment interaction between rs7248320 and exposure to smoking status on the risk of lung cancer.

Patients and methods

We conducted a hospital-based case-control study including 512 lung cancer cases and 588 healthy controls. The association between rs7248320 and the risk of lung cancer was analyzed, and the gene-environment interaction was estimated on an additive scale.

Results

The variant genotype of rs7248320 was significantly related to the risk of non-small-cell lung cancer (NSCLC). Individuals carrying homozygous GG genotype had decreased risk of NSCLC, comp

SUBMITTER: Lv X 

PROVIDER: S-EPMC5985799 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature