The biomechanics of subsynovial connective tissue in health and its role in carpal tunnel syndrome.

ABSTRACT: Carpal Tunnel Syndrome (CTS) is the most common surgically treated problem in the hand. Aside from the neuropathy itself, the most common findings are fibrosis of the subsynovial connective tissue (SSCT) and increased intra carpal tunnel pressure. Normally, the SSCT is a multilayer tissue interspersed among the carpal tendons and nerve. As the tendons move, successive SSCT layers are recruited, forming a gliding unit and providing a limit to differential movement. Exceeding this limit, damages the SSCT as has been shown in both cadavers and animal models. This damage leads to a non-inflammatory response with progressive fibrosis and nerve ischemia leaving the SSCT more susceptible to injury. Although the direct consequences for patients are not fully understood, ultrasound research shows t

SUBMITTER: Festen-Schrier VJMM 

PROVIDER: S-EPMC5985810 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature