Functional respiratory imaging: heterogeneity of acute exacerbations of COPD.

ABSTRACT:

Background

Exacerbations of COPD are a major burden to patients, and yet little is understood about heterogeneity. It contributes to the current persistent one-size-fits-all treatment. To replace this treatment by more personalized, precision medicine, new insights are required. We assessed the heterogeneity of exacerbations by functional respiratory imaging (FRI) in 3-dimensional models of airways and lungs.

Methods

The trial was designed as a multicenter trial of patients with an acute exacerbation of COPD who were assessed by FRI, pulmonary function tests, and patient-reported outcomes, both in the acute stage and during resolution.

Results

Forty seven patients were assessed. FRI analyses showed significant improvements in hyperinflation (a decrease in total volume

SUBMITTER: van Geffen WH 

PROVIDER: S-EPMC5985851 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature