Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.

ABSTRACT: Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) ¹ ; heritability estimated from twin studies ranges from 30 to 50% ² , and SNP-based heritability ranges from 6 to 15% ^3-6 . Increased neuroticism is associated with poorer mental and physical health ^7,8 , translating to high economic burden ⁹ . Genome-wide association studies (GWAS) of neuroticism have identified up to 11 associated genetic loci ^3,4 . Here we report 116 significant independent loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of these loci replicated at P < 0.00045 in an unrelated cohort (N = 122,867). Genetic signals were enriched in neuronal genesis and differenti

SUBMITTER: Luciano M 

PROVIDER: S-EPMC5985926 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature