Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

ABSTRACT: Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures reflective of interferon-related antiviral pathways were common up to day 4 of symptoms in patients who did not require mechanical ventilator support; in those who needed mechanical ventilation, an inflammatory, activated-neutrophil and cell-stress or death ('bacterial') pattern was seen, even early in disease. Identifiable bacterial co-infection was not necessary for this 'bacterial' signature but

SUBMITTER: Dunning J 

PROVIDER: S-EPMC5985949 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature