Correlation of pre-operative plasma protein concentrations in cardiac surgery patients with bleeding outcomes using a targeted quantitative proteomics approach.

ABSTRACT:

Purpose

Despite recent advancements in the use of thrombelastography (TEG) in the surgical setting, adequate technology to accurately predict bleeding phenotypes for patients undergoing cardiopulmonary bypass on the basis of non-mechanical parameters is lacking. While basic science and translational studies have provided key mechanistic insights about the protein components of coagulation cascades and regulatory mediators of hemostasis and fibrinolysis, targeted protein assays are still missing and the association of protein profiles to bleeding phenotypes and TEG readouts have yet to be discovered.

Objective

To identify protein biomarkers of bleeding phenotypes of cardiopulmonary bypass patients in pre-operative plasma.

Experimental design

We applied a targeted prote

SUBMITTER: Clendenen N 

PROVIDER: S-EPMC5985972 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature