Neuropathology of White Matter Lesions, Blood-Brain Barrier Dysfunction, and Dementia.

ABSTRACT:

Background and purpose

We tested whether blood-brain barrier dysfunction in subcortical white matter is associated with white matter abnormalities or risk of clinical dementia in older people (n=126; mean age 86.4, SD: 7.7 years) in the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study).

Methods

Using digital pathology, we quantified blood-brain barrier dysfunction (defined by immunohistochemical labeling for the plasma marker fibrinogen). This was assessed within subcortical white matter tissue samples harvested from postmortem T₂ magnetic resonance imaging (MRI)-detected white matter hyperintensities, from normal-appearing white matter (distant from coexistent MRI-defined hyperintensities), and from equivalent areas in MRI normal brains. His

SUBMITTER: Hainsworth AH 

PROVIDER: S-EPMC5986073 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature