Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance.

ABSTRACT: The development of T cell tolerance in the thymus requires the presentation of host proteins by multiple antigen-presenting cell (APC) types. However, the importance of transferring host antigens from transcription factor AIRE-dependent medullary thymic epithelial cells (mTECs) to bone marrow (BM) APCs is unknown. We report that antigen was primarily transferred from mTECs to CD8α⁺ dendritic cells (DCs) and showed that CD36, a scavenger receptor selectively expressed on CD8α⁺ DCs, mediated the transfer of cell-surface, but not cytoplasmic, antigens. The absence of CD8α⁺ DCs or CD36 altered thymic T cell selection, as evidenced by TCR repertoire analysis and the loss of allo-tolerance in murine allogeneic BM transplantation (allo-BMT) studies. Decreases in t

SUBMITTER: Perry JSA 

PROVIDER: S-EPMC5986080 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature