Endogenous Sex Hormones and Incident Cardiovascular Disease in Post-Menopausal Women.

ABSTRACT:

Background

Higher androgen and lower estrogen levels are associated with cardiovascular disease (CVD) risk factors in women. However, studies on sex hormones and incident CVD events in women have yielded conflicting results.

Objectives

The authors assessed the associations of sex hormone levels with incident CVD, coronary heart disease (CHD), and heart failure (HF) events among women without CVD at baseline.

Methods

The authors studied 2,834 post-menopausal women participating in the MESA (Multi-Ethnic Study of Atherosclerosis) with testosterone, estradiol, dehydroepiandrosterone, and sex hormone binding globulin (SHBG) levels measured at baseline (2000 to 2002). They used Cox hazard models to evaluate associations of sex hormones with each outcome, adjusting for demo

SUBMITTER: Zhao D 

PROVIDER: S-EPMC5986086 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature