Flagellum inheritance in <i>Trypanosoma brucei</i> requires a kinetoplastid-specific protein phosphatase.

ABSTRACT: Trypanosoma brucei causes sleeping sickness in humans and nagana in cattle in sub-Saharan Africa and alternates between its mammalian hosts and its insect vector, the tsetse fly. T. brucei uses a flagellum for motility, cell division, and cell-cell communication. Proper positioning and attachment of the newly assembled flagellum rely on the faithful duplication and segregation of flagellum-associated cytoskeletal structures. These processes are regulated by the polo-like kinase homolog TbPLK, whose activity and abundance are under stringent control to ensure spatiotemporally regulated phosphorylation of its substrates. However, it remains unclear whether a protein phosphatase that counteracts TbPLK activity is also involved in this regulation. Here, we report that a putative

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC5986212 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature