Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly.

ABSTRACT: Aging is accompanied by a gradual decline in both muscle mass and strength over time, which can eventually lead to pathologies, such as frailty and sarcopenia. While these two conditions are well characterized, further investigation of the early biological signs present in pre-frail elderly is still needed to help identify strategies for preventative therapeutic intervention. The goal of the present clinical study was to evaluate the level of mitochondrial (dys)function in a well-defined population of pre-frail elderly (>60 years of age). Pre-frail elderly were compared with an age-matched population of active elderly. Muscle mitochondrial function was assessed in vivo using phosphorus magnetic resonance spectroscopy (³¹P-MRS) and a comprehensive set of biological biomarkers wer

SUBMITTER: Andreux PA 

PROVIDER: S-EPMC5986740 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature