The impact of using BARCIST 1.0 criteria on quantification of BAT volume and activity in three independent cohorts of adults.

ABSTRACT: Human brown adipose tissue (BAT) is commonly assessed by cold-induced ¹⁸F-fluorodeoxyglucose (FDG) PET-CT using several quantification criteria. Uniform criteria for data analysis became available recently (BARCIST 1.0). We compared BAT volume and activity following BARCIST 1.0 criteria against the most commonly used criteria [Hounsfield Units (HU):-250, -50, standardized uptake value (SUV):2.0; HU: Not applied, SUV:2.0 and HU:-180, -10, SUV:1.5] in a prospective study using three independent cohorts of men including young lean adults, young overweight/obese adults and middle-aged overweight/obese adults. BAT volume was the most variable outcome between criteria. While BAT volume calculated using the HU: NA; SUV: 2.0 criteria was up to 207% higher than the BAT volume calculated

SUBMITTER: Martinez-Tellez B 

PROVIDER: S-EPMC5986766 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature