Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces.

ABSTRACT: A multitude of biological processes are enabled by complex interactions between lipid membranes and proteins. To understand such dynamic processes, it is crucial to differentiate the constituent biomolecular species and track their individual time evolution without invasive labels. Here, we present a label-free mid-infrared biosensor capable of distinguishing multiple analytes in heterogeneous biological samples with high sensitivity. Our technology leverages a multi-resonant metasurface to simultaneously enhance the different vibrational fingerprints of multiple biomolecules. By providing up to 1000-fold near-field intensity enhancement over both amide and methylene bands, our sensor resolves the interactions of lipid membranes with different polypeptides in real time. Significantly, we d

SUBMITTER: Rodrigo D 

PROVIDER: S-EPMC5986821 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature