Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.

ABSTRACT: Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized structures present in nails, skin, and hair, causing superficial infections known as dermatophytosis. A reasonable number of antifungal drugs currently exist on the pharmaceutical market to control mycoses; however, their cellular targets are restricted, and fungi may exhibit tolerance or resistance to these agents. For example, the stress caused by antifungal and cytotoxic drugs in sub-inhibitory concentrations promotes compensatory stress responses, with the over-expression of genes involved in cellular detoxification, drug efflux, and signaling pathways being among the various mechanisms that may contribute to drug tolerance. In addition, the ATP-binding cassette transporters in dermatophytes that are

SUBMITTER: Martinez-Rossi NM 

PROVIDER: S-EPMC5986900 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature