Association between smoking and risk of primary sclerosing cholangitis: A systematic review and meta-analysis.

ABSTRACT:

Background/objectives

Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association.

Methods

A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird.

Results

Seven case-control studies with 2,307,393 participants met the eligibility criteria and were included in the meta-analy

SUBMITTER: Wijarnpreecha K 

PROVIDER: S-EPMC5987268 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature