Increased detection of Barrett's esophagus and esophageal dysplasia with adjunctive use of wide-area transepithelial sample with three-dimensional computer-assisted analysis (WATS).

ABSTRACT:

Background

Barrett's esophagus (BE) and esophageal dysplasia (ED) are frequently missed during screening and surveillance esophagoscopy because of sampling error associated with four-quadrant random forceps biopsy (FB).

Aim

The aim of this article is to determine if wide-area transepithelial sampling with three-dimensional computer-assisted analysis (WATS) used adjunctively with FB can increase the detection of BE and ED.

Methods

In this multicenter prospective trial, patients screened for suspected BE and those with known BE undergoing surveillance were enrolled. Patients at 25 community-based practices underwent WATS adjunctively to targeted FB and random four-quadrant FB.

Results

Of 4203 patients, 594 were diagnosed with BE by FB alone, and 493 additional ca

SUBMITTER: Gross SA 

PROVIDER: S-EPMC5987273 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature