Results of surveillance in individuals at high-risk of pancreatic cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

Data on surveillance for pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals (HRIs) with "familial pancreatic cancer" (FPC) and specific syndromes are limited and heterogeneous.

Objective

We conducted a systematic review and meta-analysis of PDAC surveillance studies in HRIs.

Methods

Prevalence of solid/cystic pancreatic lesions and of lesions considered a successful target of surveillance (proven resectable PDAC and high-grade precursors) was pooled across studies. The rate of lesions diagnosed by endoscopic ultrasonography (EUS)/magnetic resonance imaging (MRI) and across different HRI groups was calculated.

Results

Sixteen studies incorporating 1588 HRIs were included. The pooled prevalence of pancreatic solid and cystic lesions was 5

SUBMITTER: Signoretti M 

PROVIDER: S-EPMC5987280 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature