Breath methane concentrations and markers of obesity in patients with functional gastrointestinal disorders.

ABSTRACT:

Background

Obesity is associated with changes in the intestinal microbiome and methane-producing archaea may be involved in energy homeostasis.

Objective

The objective of this article is to investigate the associations between intestinal methane production, waist circumference and body mass index (BMI) as biomarkers for obesity.

Methods

Breath methane and hydrogen concentrations were measured over five hours following fructose or lactose ingestion in 1647 patients with functional gastrointestinal disorders. The relationships between gas concentrations and measures of obesity were investigated by stratifying gas concentration-time profiles by BMI and waist circumference, and, conversely, BMI and waist circumference by peak breath hydrogen and methane concentrations.

SUBMITTER: Wilder-Smith CH 

PROVIDER: S-EPMC5987281 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature