Proteomic Analysis of Avian Influenza A (H7N9) Patients within a Family Cluster.

ABSTRACT:

Background

To date, there is limited information on the progression of human infections of avian influenza virus A (H7N9). This study investigated differential blood protein profiling of a H7N9-infected family cluster to find a slice of crucial proteins concerning disease attack and virus clearance.

Materials and methods

Plasma samples from one family cluster (including one index case and one asymptomatic case) were collected at four time points. The protein profiles were identified by isobaric tagging for relative and absolute quantification-based quantitative differential LC/MS/MS, and their functional annotations were analyzed by PANTHER and STRING tools.

Results

A total of 1257 nonredundant proteins were identified from 3027 unique peptides. Three differential pro

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC5987373 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature