Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice.

ABSTRACT:

Objectives

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explore whether early divergence in tibial bone mass or shape are linked to emergent OA.

Method

We undertook detailed micro-CT comparisons of trabecular and cortical bone, multiple structural/architectural parameters and finite element modelling (FEM) of the tibia from male and female STR/Ort and CBA mice at 8-10 (pre-OA), 18-20 (OA onset) and 40 + weeks (advanced OA) of age.

Results

We found higher trabecular bone mass in female STR/Ort than in either OA-prone male

SUBMITTER: Javaheri B 

PROVIDER: S-EPMC5987380 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature