Body mass index and lung cancer risk in never smokers: a meta-analysis.

ABSTRACT:

Background

Obesity is found to increase the risk of most cancer types, but reduce lung cancer risk in many studies. However, the association between obesity and lung cancer is still controversial, mainly owing to the confounding effect of smoking.

Methods

Eligible studies were identified from electric databases to July 1, 2017. Relevant data were extracted and pooled using random-effects models; dose-response and subgroup analyses were also performed.

Results

Twenty-nine studies with more than 10,000 lung cancer cases in15 million never smokers were included. Compared with normal weight, the summary relative risk (RR) was 0.77(95% confidence interval [CI]: 0.68-0.88, P < 0.01) for excess body weight (body mass index [BMI] ≥ 25 kg/m²). An inverse linear dose

SUBMITTER: Zhu H 

PROVIDER: S-EPMC5987408 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature