Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway.

ABSTRACT:

Background

Granulin epithelin precursor (GEP) is reported to function as a growth factor stimulating proliferation and migration, and conferring chemoresistance in many cancer types. However, the expression and functional roles of GEP in colorectal cancer (CRC) remain elusive. The aim of this study was thus to investigate the clinical significance of GEP in CRC and reveal the molecular mechanism of GEP in CRC initiation and progression.

Methods

The mRNA expression of GEP in CRC cell lines were detected by qRT-PCR. The GEP protein expression was validated by immunohistochemistry in tissue microarray (TMA) including 190 CRC patient samples. The clinicopathological correlation analysis were achieved by GEP expression on TMA. Functional roles of GEP were determined by MTT prolif

SUBMITTER: Pan Y 

PROVIDER: S-EPMC5987413 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature