Optimal cut-points of different anthropometric indices and their joint effect in prediction of type 2 diabetes: results of a cohort study.

ABSTRACT:

Background

To determine the anthropometric indices that would predict type 2 diabetes (T2D) and delineate their optimal cut-points.

Methods

In a cohort study, 7017 Iranian adults, aged 20-60 years, free of T2D at baseline were investigated. Using Cox proportional hazard models, hazard ratios (HRs) for incident T2D per 1 SD change in body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR), waist to hip ratio (WHR), and hip circumference (HC) were calculated. The area under the receiver operating characteristics (ROC) curves (AUC) was calculated to compare the discriminative power of anthropometric variables for incident T2D. Cut-points of each index were estimated by the maximum value of Youden's index and fixing the sensitivity at 75%. Using the derived

SUBMITTER: Zafari N 

PROVIDER: S-EPMC5987476 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature