Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory disease generally divided based on the presence or absence of nasal polyps (NPs). One of the features of NPs is excessive fibrin deposition, which is associated with down-regulation of tissue plasminogen activator (t-PA) in NPs. As t-PA is expressed in epithelial cells, and epithelium is readily accessible to topical therapies, identifying compounds that can mediate the induction of t-PA would be a potential new strategy for the treatment of NPs.

Objective

The objective of this study was to determine whether short-chain fatty acids (SCFAs) can induce t-PA in airway epithelial cells via their known receptors GPR41 and GPR43.

Methods

We performed immunohistochemistry (IHC) to determine wheth

SUBMITTER: Imoto Y 

PROVIDER: S-EPMC5987538 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature