Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis.

ABSTRACT:

Background

Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent.We sought out to examine the potential role of PAI-1 as a marker for major adverse cardiovascular events (MACE).

Methods

We systematically reviewed all indexed studies examining the association between PAI-1 and MACE (defined as death, myocardial infarction, or cerebrovascular accident) or restenosis. EMBASE, Web of Science, Medline, and the Cochrane Library were searched through October 2016 to identify relevant studies, supplemented by letters to authors and review of citations. Studies reporting the results of PAI-1 antigen and/or activity levels in association with MACE in human subjects were included.<

SUBMITTER: Jung RG 

PROVIDER: S-EPMC5987541 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature