MET alterations detected in blood-derived circulating tumor DNA correlate with bone metastases and poor prognosis.

ABSTRACT:

Background

We analyzed clinical associations of MET alterations in the plasma of patients with diverse malignancies.

Methods

Digital sequencing of circulating tumor DNA (ctDNA) (54-70 genes) was performed in 438 patients; 263 patients also had tissue sequencing (182-315 genes). The most represented tumor types were gastrointestinal (28.1%), brain (24.9%), and lung (23.2%). Most patients (71.2%) had recurrent/metastatic disease.

Results

MET alterations were observed in 31 patients (7.1%) and correlated with bone metastasis (P = 0.007), with TP53 (P = 0.001) and PTEN (P = 0.003) abnormalities, and with an increased number of alterations (median, 4 vs 1, P = 0.001) (all multivariable analyses). Patients with MET alterations demonstrated a significantly shorter median tim

SUBMITTER: Ikeda S 

PROVIDER: S-EPMC5987577 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature