Statin use and all-cause mortality in people living with HIV: a systematic review and meta-analysis.

ABSTRACT:

Background

It is unknown whether statin use among people living with HIV results in a reduction in all-cause mortality. We aimed to evaluate the effect of statin use on all-cause mortality among people living with HIV.

Methods

We conducted comprehensive literature searches of Medline, Embase, CINAHL, the Cochrane Library, and cross-references up to April 2018. We included randomised, quasi-randomised trials and prospective cohort studies that examined the association between statin use and cardio-protective and mortality outcomes among people living with HIV. Two reviewers independently abstracted the data. Hazard ratios (HRs) were pooled using empirical Bayesian random-effect meta-analysis. A number of sensitivity analyses were conducted.

Results

We included seven st

SUBMITTER: Uthman OA 

PROVIDER: S-EPMC5987595 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature