Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women.

ABSTRACT:

Background

Female gender and favorable IFNL3 genotypes are the primary independent predictors of spontaneous clearance of HCV infection. However, chronic hepatitis C infection occurs in numerous women carrying favorable IFNL3 genotypes, indicating that other host and/or virological factors contribute to the prognosis of infection.

Methods

A cohort of 137 anti-HCV-positive female Han Chinese cases, including 64 chronic HCV carriers and 73 HCV spontaneous resolvers, was recruited in the study. 111 SNPs in 23 genes encoding HCV co-receptors, transcription factors, Toll-like receptors, co-stimulating molecules, and cytokines were selected for SNP analysis.

Results

After comparison of genotypes and allelotype frequencies of 111 SNPs in 23 genes in the primary cohort, the S

SUBMITTER: Xie Z 

PROVIDER: S-EPMC5987631 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature