Chitosan gold nanoparticles induce cell death in HeLa and MCF-7 cells through reactive oxygen species production.

ABSTRACT:

Background

Nanotechnology has gained important interest, especially in the development of new therapies; the application of gold nanoparticles (AuNPs) in the treatment and detection of diseases is a growing trend in this field. As cancer represents a serious health problem around the world, AuNPs are studied as potential drugs or drug carriers for anticancer agents. Recent studies show that AuNPs stabilized with chitosan (CH) possess interesting biological activities, including potential antitumor effects that could be selective to cancer cells.

Materials and methods

In this study, we synthesized sodium citrate-AuNPs and CH-capped AuNPs of 3-10 nm, and analyzed their cytotoxicity in cervical (HeLa) and breast (MCF-7) cancer cells, and in peripheral blood mononuclear cells (P

SUBMITTER: Martinez-Torres AC 

PROVIDER: S-EPMC5987788 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature