The impact of epilepsy surgery on the structural connectome and its relation to outcome.

ABSTRACT:

Background

Temporal lobe surgical resection brings seizure remission in up to 80% of patients, with long-term complete seizure freedom in 41%. However, it is unclear how surgery impacts on the structural white matter network, and how the network changes relate to seizure outcome.

Methods

We used white matter fibre tractography on preoperative diffusion MRI to generate a structural white matter network, and postoperative T1-weighted MRI to retrospectively infer the impact of surgical resection on this network. We then applied graph theory and machine learning to investigate the properties of change between the preoperative and predicted postoperative networks.

Results

Temporal lobe surgery had a modest impact on global network efficiency, despite the disruption caused.

SUBMITTER: Taylor PN 

PROVIDER: S-EPMC5987798 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature