Altered brain high-energy phosphate metabolism in mild Alzheimer's disease: A 3-dimensional ³¹P MR spectroscopic imaging study.

ABSTRACT: In Alzheimer's disease (AD), defects in essential metabolic processes for energy supply and phospholipid membrane function have been implicated in the pathological process. However, post-mortem investigations are generally limited to late stage disease and prone to tissue decay artifacts. In vivo assessments of high energy phosphates, tissue pH and phospholipid metabolites are possible by phosphorus MR spectroscopy (³¹P-MRS), but so far only small studies, mostly focusing on single brain regions, have been performed. Therefore, we assessed phospholipid and energy metabolism in multiple brain regions of 31 early stage AD patients and 31 age- and gender-matched controls using ³¹P-MRS imaging. An increase of phosphocreatine (PCr) was found in AD patients compared with co

SUBMITTER: Rijpma A 

PROVIDER: S-EPMC5987799 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature