Education and myopia: assessing the direction of causality by mendelian randomisation.

ABSTRACT:

Objectives

To determine whether more years spent in education is a causal risk factor for myopia, or whether myopia is a causal risk factor for more years in education.

Design

Bidirectional, two sample mendelian randomisation study.

Setting

Publically available genetic data from two consortiums applied to a large, independent population cohort. Genetic variants used as proxies for myopia and years of education were derived from two large genome wide association studies: 23andMe and Social Science Genetic Association Consortium (SSGAC), respectively.

Participants

67 798 men and women from England, Scotland, and Wales in the UK Biobank cohort with available information for years of completed education and refractive error.

Main outcome measures

Mendelian r

SUBMITTER: Mountjoy E 

PROVIDER: S-EPMC5987847 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature