Disrupted modular organization of primary sensory brain areas in schizophrenia.

ABSTRACT: Abnormal brain resting-state functional connectivity has been consistently observed in patients affected by schizophrenia (SCZ) using functional MRI and other neuroimaging techniques. Graph theoretical methods provide a framework to investigate these defective functional interactions and their effects on the organization of brain connectivity networks. A few studies have shown altered distribution of connectivity within and between functional modules in SCZ patients, an indication of imbalanced functional segregation ad integration. However, no major alterations of modular organization have been reported in patients, and unambiguous identification of the neural substrates affected remains elusive. Recently, it has been demonstrated that current modularity analysis methods suffer from a fun

SUBMITTER: Bordier C 

PROVIDER: S-EPMC5987872 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature