Peripheral PDGFRα⁺gp38⁺ mesenchymal cells support the differentiation of fetal liver-derived ILC2.

ABSTRACT: Group 2 innate lymphoid cells (ILC2s) are derived from common lymphoid progenitors (CLPs) via several specific precursors, and the transcription factors essential for ILC2 differentiation have been extensively studied. However, the external factors regulating commitment to the ILC lineage as well as the sites and stromal cells that constitute the optimal microenvironment for ILC2-specific differentiation are not fully defined. In this study, we demonstrate that three key external factors, the concentration of interleukin 7 (IL-7) and strength and duration of Notch signaling, coordinately determine the fate of CLP toward the T, B, or ILC lineage. Additionally, we identified three stages of ILC2 in the fetal mesentery that require STAT5 signals for maturation: ILC progenitors, CCR9⁺

SUBMITTER: Koga S 

PROVIDER: S-EPMC5987924 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature