Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression.

ABSTRACT: A defining feature of resident gut macrophages is their high replenishment rate from blood monocytes attributed to tonic commensal stimulation of this site. In contrast, almost all other tissues contain locally maintained macrophage populations, which coexist with monocyte-replenished cells at homeostasis. In this study, we identified three transcriptionally distinct mouse gut macrophage subsets that segregate based on expression of Tim-4 and CD4. Challenging current understanding, Tim-4⁺CD4⁺ gut macrophages were found to be locally maintained, while Tim-4^-CD4⁺ macrophages had a slow turnover from blood monocytes; indeed, Tim-4^-CD4^- macrophages were the only subset with the high monocyte-replenishment rate currently attribut

SUBMITTER: Shaw TN 

PROVIDER: S-EPMC5987925 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature